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Ĭonclusion: The four AU5822 analyzers independently evaluated at three sites showed consistent precision, linearity, and correlation results.

Consequently, reference ranges required only minor or no modification with the expected exceptions of amylase, urine amylase and lipase. Slopes for amylase, tobramycin and urine amylase were 1.5, due to known methodology or standardization differences. Method comparison data showed slopes between 0.900-1.100 for 87.9% of the analytes. All analytes exhibited linearity over the analytical measurement range.

Coefficients of variation (CV) were 10% included direct bilirubin and digoxin. Results: Precision was similar among institutions. Complete data sets were available from at least one institution for 66 analytes with the following groups: 51 from all three institutions., and 15 from 1 or 2 institutions for a total sample size of 12,064. ĭesign and Methods: We independently completed performance validation studies including precision, linearity/analytical measurement range, method comparison, and reference range verification.We undertook this post-hoc multi-center study by merging our data to determine performance characteristics and the impact of methodology changes on analyte measurement. Objectives - Our three academic institutions, Indiana University, Northwestern Memorial Hospital, and Wake Forest, were among the first in the United States to implement the Beckman Coulter AU5822 series chemistry analyzers.